In general when looking for the cheapest flight to Italy, try to book your flight during the month of March for the best deal.
On average, from most locations, when planning your trip to Italy, try to book your flight in the region of 60 days in advance for the cheapest prices.
In general, booking your departure to Italy for a Wednesday represents the best deal on airfare. Try to avoid a Friday departure to stay away from the highest prices.
Generally, when visiting Italy, evening flights represent the best value. afternoon flights are likely to have higher prices.