Cheap flights from Santiago to Cusco from $178

In general, March is the cheapest month to fly from Santiago to Cusco. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $392. If you aren’t able to travel during the month of March, then book flights to Cusco from Santiago during November instead. Flights to Cusco in November, while not as cheap as those in March, still average around $406.

The cheapest day to depart on your flight to Cusco is on a Thursday when prices can be found for as low as $420. This is often the case because there is less demand to fly during this day of the week. The most expensive day to fly to Cusco is Monday, with ticket prices averaging around $823.

Our most recent data shows that the best time of day to fly to Cusco is in the afternoon. Flights from Santiago to Cusco during this time can be as low as $474. Flights to Cusco are more costly at midday, with an average ticket price of $813. Departure times at midday fall within the peak daily travel times, which is why tickets can be more expensive.

Fly from Santiago Arturo Merino Benitez to Cusco Velazco Astete for the best Santiago Arturo Merino Benitez - Cusco Velazco Astete flight prices

You are more likely to see cheaper flights to Cusco from Santiago when booking weeks ahead of your departure date. In general, you can expect to find flights to Cusco for around $437 when searching weeks before you fly. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Cusco from Santiago for as low as $381 on momondo.

There is only 1 cabin class available to choose from on Santiago to Cusco flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 14% on your flight if you consider stops on a Santiago to Cusco flight.

As of November 2026, prices for Santiago to Cusco flights are approximately 12% more expensive when compared to flights at the same time last year.

Historically, on average around 16% of flights between Santiago and Cusco have experienced a delay on any given week. The average delay length over the past 12 months has been 110 minutes.

Generally, flights departing in the early afternoon tend to experience fewer delays. Flights departing in the morning have, in the past, seen delays more frequently in comparison.

Saturday is statistically the day of the week that experiences the fewest delays on this flight route. Sunday has historically seen more delays on average compared to the rest of the week.

According to our data, LATAM Airlines have had the fewest delays on this route over the last 12 months, with about 16% of their flights experiencing any sort of delay.