Cheap flights from Santiago to Cusco from $168

In general, November is the cheapest month to fly from Santiago to Cusco. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $349. If you aren’t able to travel during the month of November, then book flights to Cusco from Santiago during March instead. Flights to Cusco in March, while not as cheap as those in November, still average around $369.

The cheapest day to depart on your flight to Cusco is on a Thursday when prices can be found for as low as $408. This is often the case because there is less demand to fly during this day of the week. The most expensive day to fly to Cusco is Wednesday, with ticket prices averaging around $471.

Our most recent data shows that the best time of day to fly to Cusco is at midday. Flights from Santiago to Cusco during this time can be as low as $402. Flights to Cusco are more costly in the evening, with an average ticket price of $471. Departure times in the evening fall within the peak daily travel times, which is why tickets can be more expensive.

Fly from Santiago Arturo Merino Benitez to Cusco Velazco Astete for the best Santiago Arturo Merino Benitez - Cusco Velazco Astete flight prices

You are more likely to see cheaper flights to Cusco from Santiago when booking weeks ahead of your departure date. In general, you can expect to find flights to Cusco for around $392 when searching weeks before you fly. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Cusco from Santiago for as low as $344 on momondo.

There is only 1 cabin class available to choose from on Santiago to Cusco flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

No. A direct flight is the cheapest option for a flight between Santiago to Cusco.

As of April 2026, prices for Santiago to Cusco flights are approximately 13% more expensive when compared to flights at the same time last year.

Historically, on average around 11% of flights between Santiago and Cusco have experienced a delay on any given week. The average delay length over the past 12 months has been 141 minutes.

Generally, flights departing in the evening tend to experience fewer delays. Flights departing in the early afternoon have, in the past, seen delays more frequently in comparison.

Wednesday is statistically the day of the week that experiences the fewest delays on this flight route. Monday has historically seen more delays on average compared to the rest of the week.

According to our data, LATAM Airlines have had the fewest delays on this route over the last 12 months, with about 11% of their flights experiencing any sort of delay.

As of April 2026, 1 flights take off from Santiago and land in Cusco each day. The most common flight departure time for this route is 14:00, with 87% of daily flights taking off in the afternoon.

As of April 2026, 9 flights take off from Santiago and land in Cusco each week. The most common flight departure day for this route is Wed, with 22% of weekly flights taking off on this day.